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Clinical Pediatrics, Vol. 21, No. 4, 217-220 (1982)
DOI: 10.1177/000992288202100404

Indomethacin for Closure of Patent Ductus Arteriosus in Prematures

Martha D. Mullett

Departments of Pediatrics and Community Medicine, West Virginia University Medical Center, Morgantown, West Virginia

Thomas W. Croghan

Departments of Pediatrics and Community Medicine, West Virginia University Medical Center, Morgantown, West Virginia

David Z. Myerberg

Departments of Pediatrics and Community Medicine, West Virginia University Medical Center, Morgantown, West Virginia

John M. Krall

Departments of Pediatrics and Community Medicine, West Virginia University Medical Center, Morgantown, West Virginia

William A. Neal

Departments of Pediatrics and Community Medicine, West Virginia University Medical Center, Morgantown, West Virginia

A controlled, double blind trial of indomethacin versus placebo was conducted in prematures of birth weight <1750 g, with a murmur of patent ductus arteriosus (PDA). The dose of indomethacin was 0.2 mg/kg for 2 doses, orally, 24 hours apart. Forty-seven patients entered the trial. Twenty-four received indomethacin and 12 of these met the criteria for response; 23 received the placebo and two met the criteria for response (p < 0.01). Subsequent surgical ligation for symptomatic PDA was required in 13 of 23 in the placebo group and 4 of 24 in the indomethacin group (p < 0.01). When administered early, indomethacin is moderately effective in closing PDA in premature infants.


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