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Clinical Pediatrics
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Propoxyphene and Acetaminophen

Possible Effects on the Fetus

Nancy L. Golden

Departments of Pediatrics, Obstetrics and Gynecology, and the Perinatal Clinical Research Center, Cleveland Metropolitan General Hospital/Case Western Reserve University, Cleveland, Ohio

Katherine C. King

Departments of Pediatrics, Obstetrics and Gynecology, and the Perinatal Clinical Research Center, Cleveland Metropolitan General Hospital/Case Western Reserve University, Cleveland, Ohio

Robert J. Sokol

Departments of Pediatrics, Obstetrics and Gynecology, and the Perinatal Clinical Research Center, Cleveland Metropolitan General Hospital/Case Western Reserve University, Cleveland, Ohio

Propoxyphene (Darvon®) and acetaminophen (Tylenol®) are widely prescribed analgesic agents. Both can cross the placenta, and propoxyphene can produce serious withdrawal symptoms in newborns. Neither propoxyphene nor acetam inophen is considered a teratogen, yet, three malformed infants who were an tenatally exposed to propoxyphene have previously been reported. We report a fourth case of an infant, with withdrawal symptoms and cranial-facial and digital malformations, born to a woman who used propoxyphene and acetaminophen throughout her pregnancy. We suggest the possibility that the antepartum use of propoxyphene and acetaminophen, in combination, may be teratogenic.

Clinical Pediatrics, Vol. 21, No. 12, 752-754 (1982)
DOI: 10.1177/000992288202101210
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Home page
 Hum Exp ToxicolHome page
P.R. McElhatton, F.M. Sullivan, G.N. Volans, and R. Fitzpatrick
Paracetamol Poisoning in Pregnancy: An Analysis of the Outcomes of Cases Referred to the Teratology Information Service of the National Poisons Information Service
Human and Experimental Toxicology, January 1, 1990; 9(3): 147 - 153.
[Abstract] [PDF]