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Clinical Pediatrics
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Influenza Vaccination in Asthmatic Children on Maintenance Theophylline Therapy

Venusto H. San Joaquin

Divisions of Infectious Diseases and Pulmonary Diseases, Department of Pediatrics, University of Oklahoma Health Sciences Center and Oklahoma Children's Memorial Hospital, Oklahoma City, Oklahoma

Santiago Reyes

Divisions of Infectious Diseases and Pulmonary Diseases, Department of Pediatrics, University of Oklahoma Health Sciences Center and Oklahoma Children's Memorial Hospital, Oklahoma City, Oklahoma

Melvin I. Marks

Divisions of Infectious Diseases and Pulmonary Diseases, Department of Pediatrics, University of Oklahoma Health Sciences Center and Oklahoma Children's Memorial Hospital, Oklahoma City, Oklahoma

Reports of toxic serum theophylline concentrations in adults following influenza vaccination prompted this study. Peak and trough serum theophylline concentrations were measured in eight severely asthmatic children before and after vaccination against influenza. All eight chil dren had been treated with chronic theophylline therapy for at least one year prior to joining the study. No significant alteration of theophylline levels were seen up to 52 hours after vac cination. No clinical evidence of drug toxicity developed.

Clinical Pediatrics, Vol. 21, No. 12, 724-726 (1982)
DOI: 10.1177/000992288202101204
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