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Clinical Pediatrics, Vol. 21, No. 11, 693-695 (1982)
DOI: 10.1177/000992288202101110

Management of Candida Peritonitis with Intravenous Amphotericin

Peritoneal Fluid Antibiotic Levels

Robert M. Levin

Department of Pediatrics, University of California, San Francisco, California

Casey Jason

Department of Pediatrics, University of California, San Francisco, California

Steve Black

Department of Pediatrics, University of California, San Francisco, California

Dorothy Nickolai

Department of Pediatrics, University of California, San Francisco, California

Donald Potter

Department of Pediatrics, University of California, San Francisco, California

Moses Grossman

Department of Pediatrics, University of California, San Francisco, California

The child presented in this report received intravenous amphotericin B 0.5 mg/ kg every 36 hours, for dialysis-associated Candida peritonitis. Just prior to her third dose of amphotericin B, the peritoneal fluid concentration of this drug was 0.1 mcg/ml, and the simultaneous serum level was 0.2 mcg/ml. An hour following the third amphotericin B dose, the peritoneal fluid and serum concentrations were 0.2 and 0.4 mcg/ml respectively. The minimal inhibitory concentration (MIC) of amphotericin B for the C. albicans isolated from this patient was 0.05 mcg/ml, and the minimal lethal concentration (MLC) was 0.1 mcg/ml. Treatment included concurrent 5-fluorocytosine, and catheter removal. This is the first time that mea surements of concentrations of amphotericin B in the peritoneal fluid have been reported in a child with peritonitis.


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