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Clinical Pediatrics, Vol. 21, No. 10, 602-606 (1982)
DOI: 10.1177/000992288202101008

Efficacy of Phototherapy and/or Exchange Transfusions in Neonatal Jaundice

Comparison of Two Eras

Nicholas Kalpoyiannis, M.D.

Neonatal Department, Alexandra Maternity Hospital, Athens, Greece

Nicholas Androulakis, M.D.

Neonatal Department, Alexandra Maternity Hospital, Athens, Greece

Emmanuel Hadjigeorgiou, M.D.

Neonatal Department, Alexandra Maternity Hospital, Athens, Greece

John Papadatos, M.D.

Neonatal Department, Alexandra Maternity Hospital, Athens, Greece

Ourania Oeconomidou, M.D.

Neonatal Department, Alexandra Maternity Hospital, Athens, Greece

Demetre Nicolopoulos, M.D.

Neonatal Department, Alexandra Maternity Hospital, Athens, Greece

In a review of treatment of neonatal jaundice, the authors studied the impact of phototherapy on outcome. From comparing exchange transfusion treatment over a 39-month period prior to the availability of phototherapy to a 39-month period incorporating phototherapy in the treatment regimen, the authors conclude that phototherapy (1) acts slowly but constantly to reduce bilirubin levels and (2) is effective even in severe hemolytic jaundice, but its effectiveness is inversely related to the degree of hemolysis. While phototherapy can never totally replace exchange trans fusion, it can certainly reduce the number of transfusions needed.


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