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Clinical Pediatrics
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Levamisole Treatment in Acute Hepatitis

A Controlled Study

Sinasi Özsoylu

Hacettepe University, Faculty of Medicine, Department of Pediatrics, Section of Hepatology, Children's Medical Center, Ankara, Turkey

Canan Sargin

Hacettepe University, Faculty of Medicine, Department of Pediatrics, Section of Hepatology, Children's Medical Center, Ankara, Turkey

Nurten Kocak

Hacettepe University, Faculty of Medicine, Department of Pediatrics, Section of Hepatology, Children's Medical Center, Ankara, Turkey

Fifty-six and forty patients with acute icteric hepatitis were given levamisole and placebo, respectively, for the first 3 days of a week of the disease for 2 weeks, and continued through the third and fourth weeks if their hepatitis was not resolved. Liver functions of the levamisole-treated patients became normal slightly faster than the controls'. The normalization time of trans aminases was found barely significantly shorter in the levamisole-treated group than in. the controls (p < 0.05). Additional studies with larger groups of antigenetically different types of hepatitis are warranted to determine whether treatment with levamisole might lessen the chances of developing chronic hepatitis.

Clinical Pediatrics, Vol. 20, No. 8, 497-500 (1981)
DOI: 10.1177/000992288102000802
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