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Septicemia in Childhood MalignancyAnalysis of 101 Consecutive EpisodesDivision of Hematology-Oncology of the Department of Pediatrics, Ohio State University, Columbus Children's Hospital, Columbus, Ohio
Division of Hematology-Oncology of the Department of Pediatrics, Ohio State University, Columbus Children's Hospital, Columbus, Ohio
Department of Pediatrics, University of Washington and the Children's Orthopedic Hospital and Medical Center, Seattle, Washington
Department of Pediatrics, University of Washington and the Children's Orthopedic Hospital and Medical Center, Seattle, Washington One hundred one consecutive episodes of blood-culture-positive infec tion were evaluated in 83 children with malignancy between 1972 and 1977. Eighty-two per cent occurred in relapse, and 75% developed when the ab solute neutrophil count was less than 500 per µl. Forty per cent were fatal. Forty-five per cent of the episodes occurring in relapse and 17% occurring in remission were fatal. Of 88 cases of single-organism infection, 46% were due to gram-positive organisms with a 13% mortality (of these, 28% were due to Staphylococcus aureus with a 4% mortality); 52% were due to gram-negative organisms with a 52% mortality; and two episodes were due to fungal organ isms with no fatalities. Multiple-organism infection occurred 13 times, of which 11 episodes were fatal. The authors' data confirm observations by others that the organisms most commonly causing blood-culture-positive infection in children with malignancy are S. aureus and Escherichia coli and that infection due to gram-positive organisms, particularly S. aureus, is less frequently fatal.
Clinical Pediatrics, Vol. 20, No. 5,
320-323 (1981) This article has been cited by other articles:
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