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Clinical Pediatrics
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Chromosomal Abnormality in the Newborns of Hepatitis B Surface Antigen (HBsAg) Carrier Mothers

Ramesh C. Jhaveri

Department of Pediatrics, The Jewish Hospital and Medical Center of Brooklyn and SUNY/Downstate Medical Center

Ram S. Verma

Department of Medicine, The Jewish Hospital and Medical Center of Brooklyn and SUNY/Downstate Medical Center, Brooklyn, New York 11238

Warren Rosenfeld

Department of Pediatrics, The Jewish Hospital and Medical Center of Brooklyn and SUNY/Downstate Medical Center

Delfor J. Salazar

Department of Pediatrics, The Jewish Hospital and Medical Center of Brooklyn and SUNY/Downstate Medical Center

Harvey Dosik

Department of Medicine, The Jewish Hospital and Medical Center of Brooklyn and SUNY/Downstate Medical Center, Brooklyn, New York 11238

Hugh E. Evans

Department of Pediatrics, The Jewish Hospital and Medical Center of Brooklyn and SUNY/Downstate Medical Center

The association of maternal hepatitis B surface antigen carriers (HBsAg) and chromosomal abnormalities in their newborns has been previously sug gested. This is a report on two female infants with abnormalities of chromosome 18 and trisomy 3q syndrome who were born to HBsAg carriers. These cases indicate that a possible relationship exists between the HBsAg carrier state in the mother and chromosome abnormalities in her offspring. It is suggested that the parents of all newborns with a structural chromosomal abnormality be tested for HBsAg.

Clinical Pediatrics, Vol. 19, No. 1, 66-68 (1980)
DOI: 10.1177/000992288001900112
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