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Clinical Pediatrics
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*VALPROIC ACID
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Sodium Valproate in the Prophylaxis of Simple Febroile Convulsions

A.J. Williams

University of Liverooot

L.G. Evans-Jones

The Royal Liverpool Children's Hospital

A.D. Kindley

The Royal Liverpool Children's Hospital

P.J. Groom

Alder Hey Children's Hospital, Liverpool, England

Thirty children with simple febrile convulsions were treated with sodium valproate following their second convulsion. Twenty-two of the 30 (73%) had no further convulsions during the one-year period of observation compared with 17 of 28 in the control group (61%). This was not a statistically signif icant difference. Side effects attributed to sodium valproate treatment were noted in 7 patients (23%), although 4 of these showed only mild transient gastrointestinal symptoms at high dosage. The study did not confirm any advantage in the use of sodium valproate as a prophylaxis for febrile con vulsions, although compliance was good and significant side effects infrequent.

Clinical Pediatrics, Vol. 18, No. 7, 426-430 (1979)
DOI: 10.1177/000992287901800710
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Home page
 Arch Pediatr Adolesc MedHome page
J. H. Antony and S. H. B. Hawke
Phenobarbital Compared With Carbamazepine in Prevention of Recurrent Febrile Convulsions: A Double-blind Study
Arch Pediatr Adolesc Med, September 1, 1983; 137(9): 892 - 895.
[Abstract] [PDF]