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Suppression of Tuberculin Reactivity During Natural Rubella

Observations with 54 Patients

Kyushu University, Japan

Sankei Nishima

Division of Pediatric Respiratory Diseases, Minami-Fukuoka National Chest Hospital, Japan, Kyushu University, Japan

Fusa Sasaki

Kyushu University, Japan

Hiromi Yoshikawa

Chemo-Sero-Therapeutic Research Institute, Okubo, Japan

Nagahide Goya

Department of Pediatrics, Kyushu University, Japan

Fifty-four patients with previously positive tuberculin reactions were fol lowed for tuberculin sensitivity, between the incubation period of natural rubella and the 40th day after the onset of rash. In many instances, tuberculin sensitivity was partially or completely depressed beginning in the incubation period and extending for up to 4 weeks after rash onset. Two of 3 cases of subclinical rubella infection also showed this phenomenon. The highest inci dence of negative reactions was 83 per cent in the first 3 days after rash onset. A few subjects had a larger skin reaction to tuberculin than the baseline reading during the 2 to 5 weeks after rash onset.

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