Clinical Pediatrics

 

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Clinical Pediatrics, Vol. 18, No. 1, 42-44 (1979)
DOI: 10.1177/000992287901800105

Reye Syndrome Associated with Vaccination with Live Virus Vaccines

An Exploration of Possible Etiologic Relationships

David M. Morens

Enteric and Neurotropic Disease Branch, Viral Diseases Division, Bureau of Epidemiology, Center for Disease Control, Atlanta, Georgia

Neal A. Halsey

Vaccine Evaluation Branch, Immunization Division, Bureau of State Services, Center for Disease Control

Lawrence B. Schonberger

Enteric and Neurotropic Disease Branch, Viral Diseases Division, Bureau of Epidemiology, Center for Disease Control, Atlanta, Georgia

Joseph V. Baublis

Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI

To determine whether vaccination with live virus vaccines may be etiologi cally related to Reye syndrome, we examined 404 cases reported to the Center for Disease Control. Fifteen of 269 children with Reye syndrome had been inoculated with live virus vaccines within 30 days before onset of illness. Although this temporal relationship may have occurred by chance, seasonal distribution and clustering of incubation periods suggests that live virus vaccines may occasionally serve as cofactors in the etiology of Reye syndrome through undefined mechanisms.


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