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Clinical Pediatrics
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Children Who Age Rapidly — Progeroid Syndromes

Case Report of a New Variant

R.H.A. Ruvalcaba

Rainier School, Buckley, Wa., Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, University of Washington, Seattle, WA

Sunchai Churesigaew

Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, University of Washington, Seattle, WA

Selma A. Myhre

Rainier School, Buckley, WA., Department of Pediatrics, University of Washington, Seattle, WA

Vincent C. Kelley

Pediatric Endocrinology and Metabolism, Department of Pediatrics, University of Washington, Seattle, WA

George M. Martin

Department of Pathology, University of Washington, Seattle, WA

A case report of an apparently unique progeroid syndrome is reported here. Major clinical characteristics included growth failure with onset of senility in the early teens, atrophic skin, hypogonadism, and retinal and vascular sclerosis. Mental retardation was present, but could have been attrib utable to trauma. The replicative life spans of several lines of cultured skin fibroblasts were within the normal range, in contrast to the limited life-spans of such cultures from patients with Werner's syndrome, whom our patient most closely resembles. Also, in contrast to Werner's syndrome, our patient did not have white or gray hair or cataracts.

Clinical Pediatrics, Vol. 16, No. 3, 248-252 (1977)
DOI: 10.1177/000992287701600308
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