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Clinical Pediatrics, Vol. 15, No. 5, 424-427 (1976)
DOI: 10.1177/000992287601500505

How Frequent Is Bacterial Superinfection of the Pharynx in Infectious Mononucleosis?

Observations on Incidence, Recognition, and Management with Antibiotics

Jane Henkel Chretien

Student Health Service, Georgetown University and the Department of Medicine, Georgetown University Hospital, Washington, D.C.

John G. Esswein

Student Health Service, Georgetown University and the Department of Medicine, Georgetown University Hospital, Washington, D.C.

Throat cultures from 133 patients with infectious mononucleosis were compared with cultures from 2,881 patients who were seen during the same period because of pharyngitis. Less than 3 per cent of the cultures from each group contained Group A beta hemolytic streptococci. The inflamed pharynx and necrotic tonsils of infectious mononucleosis are seldom subject to bacterial superinfection, either initially or during the course of the illness. There is no indication for routine use of antibiotics when infectious mono nucleosis is diagnosed. Should, however, a throat culture indicate presence of a bacterial pathogen, any appropriate antibiotic except ampicillin may be used without increasing the incidence of skin rash.


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M. C. Rush and M. W. Simon
Occurrence of Epstein-Barr Virus Illness in Children Diagnosed with Group A Streptococcal Pharyngitis
Clinical Pediatrics, June 1, 2003; 42(5): 417 - 420.
[Abstract] [PDF]

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 CLIN PEDIATRHome page
D. R. DuBois and R. L. Baehner
Infectious Mononucleosis Associated with Fatal Beta Hemolytic Streptococcal Infection
Clinical Pediatrics, August 1, 1979; 18(8): 511 - 512.
[PDF]