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Clinical Pediatrics
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Fatal Overdose from Bendectin

Marianne Bayley, M.S. (M.T.) ASCP

Toxicology Section, Department of Laboratory Medicine, National Naval Medical Center, Bethesda, Md. 20014

Lieutenant F. M. Walsh, MC, USNR

Toxicology Section, Department of Laboratory Medicine, National Naval Medical Center, Bethesda, Md. 20014

Captain M. J. Valaske, MC, USN

Toxicology Section, Department of Laboratory Medicine, National Naval Medical Center, Bethesda, Md. 20014

A three-year-old male ingested approximately 100 tablets of Bendectin. He developed tonic- clonic seizures followed by cardiac arrest. Tox icologic analysis yielded high levels of doxyl amine, dicyclomine, and pyridoxine in blood, peritoneal fluid, and tissue homogenates. The antihistamine, doxylamine succinate appears to be the toxic constituent. Analytical methods used to document the case are herein described. described.

Clinical Pediatrics, Vol. 14, No. 5, 507-514 (1975)
DOI: 10.1177/000992287501400510
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This article has been cited by other articles:


Home page
 Hum Exp ToxicolHome page
C. Koppel, J. Tenczer, and K. Ibe
Poisoning with Over-the-Counter Doxylamine Preparations: An Evaluation of 109 Cases
Human and Experimental Toxicology, September 1, 1987; 6(5): 355 - 359.
[Abstract] [PDF]