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Clinical Pediatrics, Vol. 14, No. 4, 355-368 (1975)
DOI: 10.1177/000992287501400406

Stature and Longitudinal Growth in Thalassemia Major

A Study of 229 Greek Patients

Matthew Constantoulakis, M.D., Ph.D.

2nd Department of Medicine, Hospital of the Hellenic Red Cross, Athens, Greece

George Panagopoulos, M.D.

Blood Research Laboratory, Hellenic Red Cross

Olga Augoustaki, M.D.

Blood Research Laboratory,. Hellenic Red Cross

A high percentage of Greek children with homozygous b-thalassemia were short and had a lag in growth, though some severely affected attained normal height. Bone age lagged significantly behind the chronologic age, even in those with normal height for their age.

A longitudinal study demonstrated an initial normal growth velocity which decreased after the age of six for males and eight for females. No patient had a spurt of growth at adolescence. Height gain continued up to the age of 21 and then ceased.

Statistical analysis with a multiple regression equation showed a significant relationship between the age and height of the patients. Low hemoglobin levels and severity of the disease seemed to hinder normal growth, but neither relationship was statistically significant.


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