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Clinical Pediatrics
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A Field Trial with a Live Measles-Mumps- Rubella Vaccine

Successful Use of a New Combination of Virus Strains

Vernon W. Walters

Coco Solo Hospital, Cristabol, Canal Zone, and The Dow Chemical Company, Human Health Research Laboratories, Indianapolis, Ind.

Stephen A. Miller

Coco Solo Hospital, Cristabol, Canal Zone, and The Dow Chemical Company, Human Health Research Laboratories, Indianapolis, Ind.

Joseph E. Jackson

Coco Solo Hospital, Cristabol, Canal Zone, and The Dow Chemical Company, Human Health Research Laboratories, Indianapolis, Ind.

Michael T. Kenny

Coco Solo Hospital, Cristabol, Canal Zone, and The Dow Chemical Company, Human Health Research Laboratories, Indianapolis, Ind.

Three lots of Lirutrin (measles-mumps-rubella live, attenuated virus vaccine) were evaluated in a double-blind, placebo-controlled clinical study involving 273 children. The vaccine consisted of a combination of Schwarz strain measles, Jeryl Lynn strain mumps, and Cendehill strain rubella vaccine viruses. The frequency of positive clinical findings was essentially the same in susceptible vaccinees, immune vaccinees, and placebo recipi ents ; indicating that the observed symptoms were not caused by the vaccine. Antibody assay of paired serum samples revealed that measles, mumps, and rubella seroconversion rates in triple susceptible vaccinees were excellent, ranging from 96 to 98 per cent with all three lots com bined. Results of this study show that Lirutrin trivalent vaccine is well tolerated and highly effective.

Clinical Pediatrics, Vol. 14, No. 10, 928-933 (1975)
DOI: 10.1177/000992287501401009
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Home page
 Arch Pediatr Adolesc MedHome page
T. Vesikari, E.-L. Ala-Laurila, A. Heikkinen, A. Terho, E. D'Hondt, and F. E. Andre
Clinical Trial of a New Trivalent Measles-Mumps-Rubella Vaccine in Young Children
Arch Pediatr Adolesc Med, September 1, 1984; 138(9): 843 - 847.
[Abstract] [PDF]