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Clinical Pediatrics, Vol. 13, No. 3, 273-279 (1974)
DOI: 10.1177/000992287401300313

Ampicillin Blood Levels as Related to Graded Oral Schedules

The Minimal Effect of Ampicillin-Associated Diarrhea upon Drug Absorption and Other Therapeutic Considerations

James W. Bass

Department of Pediatrics, Tripler Army Medical Center, Department of Pediatrics, University of Hawaii School of Medicine, Honolulu, Hawaii

Dennis M. Crowley

Department of Pediatrics, Tripler Army Medical Center, Department of Pediatrics, University of Hawaii School of Medicine, Honolulu, Hawaii

Russell W. Steele

Department of Pediatrics, Tripler Army Medical Center, Department of Pediatrics, University of Hawaii School of Medicine, Honolulu, Hawaii

Franklin S. H. Young

Department of Pediatrics, Tripler Army Medical Center, Department of Pediatrics, University of Hawaii School of Medicine, Honolulu, Hawaii

Lewis B. Harden

Department of Pediatrics, Tripler Army Medical Center, Department of Pediatrics, University of Hawaii School of Medicine, Honolulu, Hawaii

Twenty children, while hospitalized with pneu monia, were treated by randomization with graded dosages of oral ampicillin; five each received 50, 100, 150, or 200 mg/kg daily in four equally divided doses for at least five days. The peak serum levels rose from a mean of 1 mcg/ml with 50 mg/kg per day to 4 to 7 mcg/ml with 200 mg/kg per day. Mild to moderate diarrhea, encountered in two of the five patients of each study group, was apparently unrelated to dose, and did not hinder absorption of the drug to a clinically significant degree.


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