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Clinical Pediatrics
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Acute Splenic Sequestration Crises (ASSC) in Young Children with Sickle Cell Anemia

Clinical Observations in 20 Episodes in 14 Children

Ruth Andrea Seeler

Cook County Hospital, Hektoen Institute for Medical Research of the Cook County Hospital, Abraham Lincoln School of Medicine of the University of Illinois College of Medicine

M. Ziad Shwiaki

Pediatric Hematology, Cook County Hospital

Acute splenic sequestration crises (ASSC) is a potentially life-threatening com plication in young children with sickle cell anemia. The clinical picture includes huge splenomegaly accompanied by signs and symptoms of acute circulatory insufficiency caused by profound anemia. The authors describe 20 such episodes in 14 children aged six to 55 months. Rapid transfusion of packed erythrocytes produced rapid and dramatic improvement. The spleens became nonpalpable in seven to ten days following transfusion. Four children died, four had one or more recurrences, four have splenic involution, and two were splenectomized. The recurrences were within four months of the previous ASSC. "Our current recommendation is to consider splenectomy only after at least two ASSCs."

Clinical Pediatrics, Vol. 11, No. 12, 701-704 (1972)
DOI: 10.1177/000992287201101214
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This article has been cited by other articles:


Home page
 CLIN PEDIATRHome page
C. S. Alvarado, B. Wyly, I. Buchanan, and W. A. Fajman
Splenic Infarction at Low Altitude in a Child with Hemoglobin S-C Disease
Clinical Pediatrics, August 1, 1988; 27(8): 396 - 399.
[Abstract] [PDF]

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 JAMAHome page
M. L. Mills
Life-Threatening Complications of Sickle Cell Disease in Children
JAMA, September 20, 1985; 254(11): 1487 - 1491.
[Abstract] [PDF]

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 CLIN PEDIATRHome page
J. Andrews and G. R. Buchanan
Mild Splenic Sequestration Crises in Sickle-Hemoglobin C Disease
Clinical Pediatrics, June 1, 1984; 23(6): 354 - 355.
[Abstract] [PDF]