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Clinical Pediatrics, Vol. 11, No. 12, 693-697 (1972)
DOI: 10.1177/000992287201101211

Regional Lymphadenitis Following BCG Vaccination (BCGitis)

Clinical Comments Based Upon 25 Instances Among 1295 Childhood Vaccinees

Enrique Chaves-Carballo

Pediatric Service, Gorgas Hospital, Canal Zone

Gil A. Sanchez

Pathology Service, Gorgas Hospital, Canal Zone

Among 1,295 children vaccinated with BCG during a 16-month period, 25 developed regional lymphadenopathy (BCGitis) for an incidence of 1.9 per cent. In half of the cases, the enlarged nodes progressed to suppuration, most often in infants. Different lots of BCG varied in their capability to induce BCGitis. Technic in administration did not ap pear to be related to this complication. Subsequent change from fluid to freeze-dried vaccine markedly reduced the incidence of BCGitis.


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Y. Kobayashi, Y. Komazawa, M. Kobayashi, T. Matsumoto, N. Sakura, K. Ishikawa, and T. Usui
Presumed BCG Infection in a Boy with Chronic Granulomatous Disease: A Report of a Case and a Review of the Literature
Clinical Pediatrics, October 1, 1984; 23(10): 586 - 589.
[Abstract] [PDF]