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Clinical Pediatrics
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Disseminated Intravascular Coagulation Complicating Propylthiouracil Therapy

A Case Description of a 16-Year-Old Girl

T. James Sammon, M.D.

of Pediatrics and Pathology , St. Louis University School of Medicine, Cardinal Glennon Memorial Hospital for Children, 1465 South Grand Avenue, St. Louis, Missouri 63104

Virginia H. Peden, M.D.

of Pediatrics and Pathology , St. Louis University School of Medicine, Cardinal Glennon Memorial Hospital for Children, 1465 South Grand Avenue, St. Louis, Missouri 63104

Camillus Witzleben, M.D.

of Pediatrics and Pathology , St. Louis University School of Medicine, Cardinal Glennon Memorial Hospital for Children, 1465 South Grand Avenue, St. Louis, Missouri 63104

James P. King, M.D.

of Pediatrics and Pathology , St. Louis University School of Medicine, Cardinal Glennon Memorial Hospital for Children, 1465 South Grand Avenue, St. Louis, Missouri 63104

A 16-year-old girl with thyrotoxicosis, treated successfully for two years with propylthiouracil, developed a purpuric rash, prolonged pro- thrombin time, increased split fibrin products, elevated antinuclear anti body titer and glomerular changes. The symptoms abated after ther apy with heparin and prednisone, although the ANA titer remained elevated. This is presented as the first reported instance of dissem inated intravascular clotting resulting from propylthiouracil therapy.

Clinical Pediatrics, Vol. 10, No. 12, 739-742 (1971)
DOI: 10.1177/000992287101001221
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D. B. Vasily and W. B. Tyler
Propylthiouracil-Induced Cutaneous Vasculitis: Case Presentation and Review of the Literature
JAMA, February 1, 1980; 243(5): 458 - 461.
[Abstract] [PDF]