This Article Full Text (OnlineFirst PDF) All Versions of this Article: 0009922808315212v1 47/6/549    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Casey, J. R. Articles by Pichichero, M. E. Search for Related Content PubMed PubMed Citation Articles by Casey, J. R. Articles by Pichichero, M. E. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB AMOXICILLIN Medline Plus Health Information Antibiotics Sore Throat Streptococcal Infections Tonsils and Adenoids Social Bookmarking                         What's this?

Frequency of Symptomatic Relapses of Group A -Hemolytic Streptococcal Tonsillopharyngitis in Children from 4 Pediatric Practices Following Penicillin, Amoxicillin, and Cephalosporin Antibiotic Treatment

^* To whom correspondence should be addressed. E-mail: michael_pichichero{at}urmc.rochester.edu.

	Abstract

The objective was to determine the frequency of early symptomatic relapses following antibiotic treatment for group A -hemolytic streptococcal (GABHS) tonsillopharyngitis in children from Rochester, New York; Houston, Texas; Spokane, Washington; and Los Angeles, California (2004-2006). The study included 4278 patients. The proportion with a bacteriologic relapse of GABHS tonsillopharyngitis within 1 to 5 days of completing a 10-day treatment course was 8% (penicillin and bicillin), 6% (amoxicillin), 2% (first-generation cephalosporin), and 1% (second-generation and thirdgeneration cephalosporin; P = .0001); symptomatic relapses occurred within 6 to 20 days after completion of therapy in 16%, 14%, 9%, and 7% of cases (P = .0001). Cases from New York and Washington had higher penicillin or amoxicillin failure rates than cases from Texas and California. The frequency of symptomatic relapses of GABHS tonsillopharyngitis, therefore, differs according to the antibiotic treatment selected; the trend for such relapses being penicillin or amoxicillin > cephalosporins although geographic differences may occur.

First published on May 19, 2008, doi:10.1177/0009922808315212

Clinical Pediatrics 2008;47:549.

A more recent version of this article appeared on July 1, 2008


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?